The episode title refers to the movie of the same name.
This episode marks the second episode where Melissa, Todd, Erica, and Gail make no appearance after their introduction, the first episode being "Is There Anybody Out There?". This episode also marks the first episode where Carol doesn't appear. Simultaneously, present-day Phil does not make an appearance. However, a younger version of Phil, portrayed by Jacob Tremblay appears in two of Mike's dreams. Phil is also mentioned by Mike numerous times.
Willie Nelson's "Blue Eyes Crying in the Rain" plays as Mike pedals on his Aqua-Cycle.
"Up on Cripple Creek" by The Band plays as Mike exits Miami Beach.
"Blue Bayou" by Linda Ronstadt plays as Mike and Pat drink scotch and talk on the boat.
A young Phil is shown swimming in a baby pool with red Kool-Aid.
Mike changes into Simpsons themed boxers, when he first arrives on Pat's boat.
Pat's boat, "Deez Knots", parodies the popular Internet meme, "Deez Nuts".
It is revealed that the virus that affected the human population was due to a disease that caused internal leaking of blood through every hole of the body.
It is explained by Pat that the deceased bodies of the virus were located at triage operations located in every city, or at their own homes.