The title references the Spirit of St. Louis, the custom-built, single engine, single-seat monoplane that was flown solo by Charles Lindbergh.
This is the final appearance of Lewis Ha, who dies from an explosion as a result of crashing his airplane.
Gail makes no appearance in this episode, with an exception in the very last seconds of the episode. Her fingers are seen moving and her body is briefly shown.
Erica is clearly able to identify multiple types of prescription drugs.
A post-virus newspaper by Carol reveals that Lewis' last name is Ha.
The second edition's story mainly features Carol's offer to bejewel Lewis' bomber jacket, which she then notes that "without the jewels, it looks like a simple one from Top Gun."
Carol performs The Roger Rabbit Dance, an old hip-hop dance that gained its popularity from the movie, Who Framed Roger Rabbit?.
The full list of celebrities Phil lists in his toast, pump-up speech, and eulogy includes Galileo, Sir Isaac Newton, Thomas Alva Edison, Doug Henning, Pelé, Peter Frampton, Jonas Salk, Lena Dunham, Shel Silverstein, Kenny Loggins, George Washington Carver, Nelson Mandela, Jim Henson, Hamilton, the guy who did Hamilton, Neil Armstrong, Johnny Appleseed, SEAL Team Six and Ryan Lochte, before his incident in Rio.
The Kinks' "I Gotta Move" plays during Phil's montage of setting up the lights.